ESTD : 1897 | TYPE : Government | AFFILIATION : WHO | RECOGNITION : MCI
A world-class university (with three essential qualities – comprehensive, research-intensive, and innovative) that will transform lives and improve China and the world
To nurture future leaders and useful citizens with a global vision and social responsibility;
To conduct interdisciplinary and innovative research that addresses pressing challenges facing the world today;
To translate knowledge and creativity to benefit the local and global communities.
求是创新
Seeking Truth, Pursuing Innovation
The University logo consists of two components: the round emblem and the wordmark.
The round emblem features a flying eagle in the center, a ZJU mascot known as the “qiushi eagle”. The eagle symbolizes the University’s tradition of seeking truth and pursuing innovation, which has been inherited and further developed by the ZJU community.
Normally, the wordmark must always appear in conjunction with the emblem. If desired, the emblem may be used alone (for instance, when space is limited).
| # | Course | Seats | 1st Yr Fee | From Next Yr | Total Fee | Cash Back | Lodging Fee | Fooding Fee | Course Duration |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MBBS | 60 | RMB -51,800 =INR- 5, 18,000 | RMB- 48,800= INR- 3,43,800 | RMB-2,47,000=INR-2,470,000 | INR-10000 | lodging included first year package | RMB-100=INR-6,500 | 5 YEARS |
ADMISSION PROCESS
STEP-1
REGISTRATION
Send us scan copy of your 10thand 12th Document with scan of your passport size photographinfo@imaginecareer.in/www.imaginecareer.in
And send the registration amount to the given account number.
STEP-2
ADMISSION CONFIRMATION
As soon as the admission latter comes you need to submit the second
Installment of the processing charge with original passport, original documents with some additional documents as instructed.
STEP-3
VISA APPLICATION
Once the documents has been submitted at the Embassy and the visa receiving data has been confirmed, the student need to give the third installment..As Soon as the passport will be received with visa stamping, all the originals will be given back.
STEP-4
TRAVEL INFORMATION
about the departure The last step is the travel arrangements which will be done by us, we will be giving you all the necessary details time ,
Arrival time ,who will be receiving at the airport etc.The last installment of the processing fee will be given them.
STEP-5
FOODING EXPENSES
i).1$=INR 65(Approx for calculation) Actual rate at the time of fees payment will be calculated.
ii).Medical Checkup, Medical Insurance and Visa Extension is included in Package, Food Expenses $100 per month.
iii).Fee given in the chart is approx. Actual fee will be known when you choose t
Discovering Ketamine’s antagonist
In the first article, HU’s team found that ketamine blocks bursting activity in the lateral habenula (LHb), an anti-reward center in the brain, to rapidly relieve depression. They discovered that in various animal models of depression, the intrinsic burst firing activity of LHb neurons is significantly increased. Burst firing, a particular spike pattern with clusters of high-frequency spikes, provides a robust form of information coding and a stronger output from LHb to inhibit the reward-related dopaminergic and serotonergic centers.
A model for mechanisms of depression and ketamine treatment in LHb: Upregulation of Kir4.1 on astrocytic processes surrounding neuronal soma leads to enhanced K+ buffering at the tight neuron-glia junction, decreased Kout and hyperpolarized neuronal RMP. Consequently, de-inactivation of T-VSCCs initiates NMDAR-dependent bursts, causing a stronger output of LHb to trigger depression. Ketamine blockade of NMDARs stops bursts and relieves depression.
The team discovered that LHb burst firing strongly depends on NMDAR, a major subtype of excitatory glutamate receptors within the brain. Ketamine, as a NMDAR antagonist, completely eliminates LHb bursting in vitro and reduces bursting of depressive-like animals to the level of naïve control animals in vivo.
Collectively, these data suggest a simple and novel mechanism whereby ketamine quickly elevates mood by instantaneously blocking NMDAR-dependent bursting activity of LHb to disinhibit downstream dopaminergic and serotonergic neurons.
Going deeper: molecular determinant of depression
In the second research article, the team further identified the molecular mechanism by which neuron-glia interaction at the LHb regulates burst firing in depression. Through an unbiased, mass spectrometry-based, quantitative proteomic screening, they identified an inward-rectifying potassium channel, Kir4.1, which is upregulated in depression. Kir4.1 is exclusively expressed in the astrocytes, one type of glia cells, in the LHb.
The results point to the important role of a glia-specific ion channel in the regulation of neuronal firing pattern, and provide compelling evidence for Kir4.1 being a powerful molecular determinant of depression.
Far-reaching implications
The two articles, with one addressing how LHb neurons increase burst firing in depression and the other revealingthis burst firing to be a prominent target of rapid antidepressant ketamine, make a strong case that the firing mode of LHb neurons is critical in depression.
The newly discovered structure-function mechanism at the glial-neural interface in burst regulation may enrich our understanding of the basic cell biology of how glia regulates neural activity in physiological and pathological states.
Together, they provide a new framework for understanding the molecular, cellular and circuit mechanism of depression and shed important light on developing new rapid-acting antidepressants.
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